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Tuberculosis

BACTEC MGIT 960 SIRE – Drug Susceptibility Testing of Tuberculosis Bacilli
Czas oczekiwania: Culture (4 to 42 days) plus an additional 4 to 21 days Waiting time: Culture (4 to 42 days) plus an additional 4 to 21 days

When should the test be performed?
BACTEC MGIT 960 SIRE is a qualitative method for assessing the susceptibility of Mycobacterium tuberculosis to first-line anti-tuberculosis drugs. The test is recommended in cases of:

  • Confirmed tuberculosis infection
  • Need to determine the effectiveness of anti-TB therapy
  • Suspected multidrug-resistant tuberculosis (MDR-TB)
  • Monitoring mycobacterial resistance during treatment
  • Epidemiological and clinical investigation of strains

Test description
The BACTEC MGIT 960 SIRE method uses MGIT (Mycobacteria Growth Indicator Tube) liquid medium in the automated BACTEC MGIT 960 system to quickly and accurately assess susceptibility to the key first-line anti-TB drugs:

  • Streptomycin (S)
  • Isoniazid (I)
  • Rifampicin (R)
  • Ethambutol (E)

The test detects bacterial growth in the presence of critical concentrations of these drugs. The automated BACTEC MGIT 960 system continuously monitors samples and records results, eliminating the need for subjective interpretation. Compared to classical phenotypic methods, this test is faster and allows for earlier treatment adjustments.

Diagnostic significance
BACTEC MGIT 960 SIRE is a vital tool in the diagnosis of drug-resistant tuberculosis, enabling effective adjustment of treatment regimens. Early detection of resistance to first-line drugs allows for the prompt initiation of appropriate therapy and helps reduce the spread of drug-resistant M. tuberculosis strains.

Test results
Results are available electronically or for in-person collection. The Center for Clinical Medicine provides comprehensive tuberculosis diagnostics, offering modern drug susceptibility testing and support in effective anti-tuberculosis treatment strategies.

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